Combining functional and structural genomics to sample the essential Burkholderia structome.
BACKGROUND:The genus Burkholderia includes pathogenic gram-negative bacteria that cause melioidosis, glanders, and pulmonary infections of patients with cancer and cystic fibrosis.Drug resistance has made ultrastar dc hc550 development of new antimicrobials critical.Many approaches to discovering new antimicrobials, such as structure-based drug des